Imagine this: a magic pill that could help you lose weight without worrying about your diet and workout routine. This dream may seem far out of reach, but we’re not far off.

It may not be magical, but Tsofensine works for weight loss. In fact, clinical trials have shown that it works 2.5-8.6% more than diet changes, according to the dosage patients were on.

The Tesofensine benefits are endless, and it’s time that you check it out. Keep reading to learn more.

What Is Tesofensine?

Tesofensine is a noradrenaline, dopamine, and serotonin reuptake inhibitor. This means that the medication prevents our synapses from taking these neurotransmitters away. In turn, we’re left with more noradrenaline, dopamine, and serotonin in our system.

This mechanism may sound familiar because mental health medications, including eating disorder medications, use a similar process. However, these medications don’t produce the weight loss many patients look for.

Originally, researchers looked at Tesofesine as a potential treatment for Parkinson’s and Alzheimer’s. However, in clinical trials, patients began losing too much weight. The extreme weight loss put the trial on hold.

Because of this finding, scientists began analyzing the medication for use in patients looking to lose weight.

How Tesofensine Works

After shifting their focus toward Tesofensine as a weight loss drug, scientists found that it reduces the patient’s appetite. By stimulating our cholinergic system, tesofensine has become more successful than average weight loss remedies.

Our cholinergic systems regulate a variety of systems in our bodies, including sensory processing, attention, sleep, and arousal. So, stimulating this system allows our bodies to work faster than normal.

Additionally, Tesofensine increases the near transmission of monoaminergic neurotransmitters, which regulate energy balance. Each of the neurotransmitters it affects has a connection to obesity and depression. By increasing these neurotransmitters, Tesofenine is reducing the chance of both obesity and depression.

What Are the Tesofensine Benefits?

There have been a few research studies that have looked at how Tesofensine works in a variety of patient cases. In these studies, we’ve learned a lot about Tesofensine:

  • It increases energy metabolism
  • It suppresses appetite
  • It improves patients’ quality of life
  • It betters body composition
  • It is neuroprotective
  • It leads to improved insulin sensitivity
  • It has anti-depressant effects

While Tesofensine has multiple benefits for all patients, its weight loss properties primarily benefit patients with diet-induced obesity, which is one of the top health problems worldwide.

In patients with obesity secondary to other factors, the medication may not have direct effects.

The medication causes a decrease in appetite. If appetite isn’t the problem, it cannot cause effective weight loss.

Tesofensine Side Effects

So far in clinical trials, Tesofensine has shown minimal side effects. These include the following:

  • Dry mouth
  • Insomnia
  • Tachycardia (high heart rate)
  • Constipation
  • Diarrhea
  • Nausea
  • Hypertension (high blood pressure)

If you experience these side effects while taking the medication, let your physician know. They may want to adjust your dose or consider a second medication to remedy existing side effects.

How Does Tesofensine Weight Loss Work?

Tesofensine is a triple reuptake inhibitor. It targets serotonin, noradrenaline, and dopamine receptors.

Each of these receptors is important in identifying how Tesofensine works with weight loss. And, together, they explain how Tesofensine is able to have such a strong effect on weight loss.

As a triple reuptake inhibitor, Tesofensine stands out against other weight loss medications.


Serotonin is a neurotransmitter that plays a role in multiple bodily functions. These functions include the following:

  • Mood
  • Sleep
  • Digestion
  • Nausea
  • Wound healing
  • Blood clotting
  • Bone health
  • Sexual desire

Overall, the neurotransmitter controls our happiness, satisfaction, and optimism. Patients with too little serotonin are more likely to have conditions like chronic depression. They’re also more likely to overeat because they’re less likely to get satisfied quickly.

Tesofensine has a similar mechanism to SSRIs (selective serotonin reuptake inhibitors), which is the most common treatment for chronic depression. By preventing our bodies from picking up extra serotonin, these medications are supplying us with more free serotonin.

More serotonin increases our ability to feel happiness and satisfaction. So, we’re less likely to feel depressed and less likely to overeat.


Noradrenaline, also known as norepinephrine, is both a neurotransmitter and a hormone. It plays a role in controlling the body’s flight-or-fight response.

Low levels of noradrenaline in the body can lead to sluggishness and fatigue. On the other hand, high levels of noradrenaline can increase fat loss and get the blood pumping faster.

By targeting this neurotransmitter, Tesofensine may be increasing patients’ metabolic rates. This means that patients can eat more without gaining extra weight.

At the same time, patients will be able to start burning fat more. Considering the dangerous effects of extra body fat, tesofensine can decrease risk factors associated with obesity. These include diabetes, cancer, hypertension, and insulin sensitivity.


Dopamine is a neurotransmitter that helps produce feelings of satisfaction and pleasure. When dopamine isn’t in the right balance, we can start losing the ability to feel satiated.

Those with diet-induced obesity may eat so much food that they begin dampening their dopamine receptors. This means that their bodies can no longer recognize whether they’re full or not, causing them to eat more than they normally would.

In fact, about 70% of patients who are obese have fewer dopamine receptors than patients of normal weight.

By inhibiting dopamine transport proteins (which get rid of dopamine), Tesofensine can increase the levels of dopamine in the brain. In turn, our bodies feel satisfied faster, leading to less eating.

Tesofensine may also be able to reverse dopamine blunting in patients with diet-induced obesity.

Buying Tesofensine Online

If you’re trying to lose weight, you aren’t alone. In fact, nearly half of the United States’ adult population is trying to lose weight.

You don’t have to go through your weight loss journey alone. You can trust our team at New Results Medical Weight Loss. Start with our first program, prescription appetite suppressant to see Tesofensine benefits for yourself.

No matter where you are on your weight loss journey, our team can help.

Providing The Best Medical Weight Loss in Scottsdale and Mesa

Ready to say goodbye to extra weight for good? New Results Medical Weight Loss can help. Our success comes from the fact that our weight loss protocols are medically sound and individualized to each person. Since 2009, New Results Medical Weight Loss has helped thousands of men and women in the Valley look and feel their best, and we can help you, too.

Explore our medical weight loss programs or contact us today to schedule a free consultation with one of our weight loss experts.