Dopamine, norepinephrine, and serotonin neurotransmitters are responsible for balancing energy and are related to depression and obesity. Tesofensine works by increasing the transmission of neurotransmitters in the brain. The neurotransmitter Dopamine release produces the feeling of pleasure and satisfaction in the brain.
When the dopamine level is not balanced, our body may lose its many benefits. Lowered dopamine in the body can result in behavioral changes and dopamine adaptation. Reduced dopamine can alter the brain signals, resulting in glucose intolerance, obesity, and weight gain.
Normal weight people have a higher number of dopamine receptors when compared to heavyweight people. It can be because of two reasons. To start with, overweight people may already have a lower number of dopamine receptors, or, on the other hand, it is their body’s way of compensating for higher dopamine levels as a result of overeating.
Maintaining body weight is a complex process involving a lot of neurotransmitter actions and physiological mechanisms. For example, balancing the dopamine levels or dopamine receptor deficiency in overweight people may reduce their food intake, eventually leading to weight loss.
Tesofensine inhibits the dopamine transporter proteins. As a result, it stimulates the dopamine receptor for a longer duration, and as a result, the brain keeps producing the feeling of satisfaction. Similarly, the use of Tesofensine also showcases an increase in the other two monoamine neurotransmitters, noradrenaline and serotonin.
Both transmitters play an essential role in maintaining the metabolism and appetite by simulating different brain parts. These two neurotransmitters work in the hypothalamus section of the brain to reduce appetite and increase metabolism. At the same time, dopamine works in the nucleus accumbens section of the forebrain, which modulates the feeling of satisfaction and pleasure in eating food.
Using Tesofensine peptide with a calorie deficit diet has the potential to reverse the dopamine adaptation in overweight patients. Combining this with regular exercise, which increases dopamine production, might be a one-stop solution for weight loss.