All About Tesofensine and Its Benefits

Tesofensine (NS2330) comes from the phenyltropane drugs family and is a presynaptic noradrenaline, dopamine, and serotonin reuptake inhibitor. This medication prevents the central nervous system from reabsorbing the three neurotransmitters dopamine, serotonin, and noradrenaline. This process results in reducing hunger.

Tesofensine peptide works by reducing appetite while simultaneously increasing resting energy expenditure and fat oxidation. It also modulates the action of dopamine which influences a particular section of the brain to replicate the pleasure sensation of consuming food.

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Origin Of Tesofensine

Dopamine, norepinephrine, and serotonin neurotransmitters are responsible for balancing energy and are related to depression and obesity. Tesofensine works by increasing the transmission of neurotransmitters in the brain. The neurotransmitter Dopamine release produces the feeling of pleasure and satisfaction in the brain.

When the dopamine level is not balanced, our body may lose its many benefits. Lowered dopamine in the body can result in behavioral changes and dopamine adaptation. Reduced dopamine can alter the brain signals, resulting in glucose intolerance, obesity, and weight gain.

Normal weight people have a higher number of dopamine receptors when compared to heavyweight people. It can be because of two reasons. To start with, overweight people may already have a lower number of dopamine receptors, or, on the other hand, it is their body’s way of compensating for higher dopamine levels as a result of overeating.

Maintaining body weight is a complex process involving a lot of neurotransmitter actions and physiological mechanisms. For example, balancing the dopamine levels or dopamine receptor deficiency in overweight people may reduce their food intake, eventually leading to weight loss.

Tesofensine inhibits the dopamine transporter proteins. As a result, it stimulates the dopamine receptor for a longer duration, and as a result, the brain keeps producing the feeling of satisfaction. Similarly, the use of Tesofensine also showcases an increase in the other two monoamine neurotransmitters, noradrenaline and serotonin.

Both transmitters play an essential role in maintaining the metabolism and appetite by simulating different brain parts. These two neurotransmitters work in the hypothalamus section of the brain to reduce appetite and increase metabolism. At the same time, dopamine works in the nucleus accumbens section of the forebrain, which modulates the feeling of satisfaction and pleasure in eating food.

Using Tesofensine peptide with a calorie deficit diet has the potential to reverse the dopamine adaptation in overweight patients. Combining this with regular exercise, which increases dopamine production, might be a one-stop solution for weight loss.

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Outcomes Of Clinical Trials of Tesofensine

A 28-week Phase II clinical trial of 203 people showcased positive results of Tesofensine in weight loss. Patients on 0.25 mg of Tesofensine, the lowest dose, had an average weight loss of 6.5% and 11.2% in those on a medium dose of 0.5 mg. Patients on the highest dose of 1 mg tesofensine showcased 12.6% weight loss. The medium and high-dose patients also have a 4-point reduction in their BMI.

Apart from this, Tesofensine also showcased the following results.

  • Reduced appetite within 14 days, patients have lowered desire to eat with an increased level of satiety.
  • It showcased a 6% increase in energy expenditure at rest after 14 days. It is a direct benefit of Tesofensine without any other factor serving as the possible cause.
  • The insulin sensitivity level improved with high glucose metabolism in patients. Patients at risk of type 2 diabetes can potentially benefit from this.
  • The fat tissue reduction and fat oxidation also increased significantly in patients. It resulted in a 15% increase in fat oxidation in 24 hours. Protein oxidation is also reduced.

Benefits Of Tesofensine

When used with a calorie deficit diet and a physical activity level of 30-60 minutes per day in the clinical trials, Tesofensine benefits are immense. The positive results in the test subjects include

  • Reduction in body weight and BMI
  • Improved waist-to-hip ratio
  • Reduced triglycerides and very-low-density lipoprotein
  • Reduction in body fat
  • Reduced visceral fat
  • Reversing effect on type 2 diabetes

Side Effects Of Tesofensine

Tesofensine’s side effects are generally similar to other weight loss medications, and can include:

  • Insomnia
  • Dry mouth
  • Constipation
  • Tachycardia
  • Diarrhea
  • Nausea
  • Constipation
  • Increased heart rate
  • High blood pressure
image of bottled Tesofensine for weight loss

About New Results Medical Weight Loss

New Results Medical Weight Loss has been helping patients in Arizona improve their health since 2009. With locations in Scottsdale and Mesa, we provide integrative healthy aging products and holistic medical weight loss programs for patients throughout the Valley.

If you have questions about hormone optimization, Peptide therapy, or any of our other weight loss and wellness optimization programs, contact us online or call to schedule your free consultation.

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Our programs and products are intended to help patients achieve the best possible levels of health and wellness despite natural processes in the body associated with middle and old age.